Antipyretic Effectiveness Test of Ethanol Extract of Kaempferia Galanga L. Rhizoma in DPT Vaccine-Induced Wistar Rats

Abstract

Introduction: Antipyretics is another name for no fever, which is where the body temperature increases, which can be caused by infection, immunization factors.

Objective: This study was to determine the effect of extracting kaempferia galanga  rhizomes on temperature reduction in wistar rats of fever induction DPT vaccine.

Methods: The DPT vaccine has side effects, one of which is fever, particularly in the proximal portion. Thirty-six male Wistar rats were divided into six groups. Group 1 was the normal group, uninjected with DPT vaccine. Groups II, III, IV, V, and VI were induced with 0.2 ml of DPT vaccine intramuscularly. Group II, the negative control, was given 0.5% CMC-Na. Group III served as the positive control with 5 ml of paracetamol suspension. Groups IV, V, and VI were given 0.5%, 0.75%, and 1% galangal extract, respectively. The temperature of each rat was measured every 30 minutes for 180 minutes.

Results: The antipyretic effect began to be seen in the 60th minute. The average temperature reduction of various groups was 0.04◦C, 0.04◦C, 0.29◦C, 0.25◦C, 0.22◦C and 0.28◦C. Ethanol extract of kencur rhizome contains flavonoid, saponin and terpenoid compounds. Ethanol extract of kaempferia galanga rhizome has the potential as an antipyretic or anti-fever, at a dose of 1% is the optimum dose used as an antipyretic.

Conclusion: Ethanol extract of kaempferia galanga rhizome contains flavonoid, saponin and terpenoid compounds, and has the potential as an antipyretic or anti-fever with an optimum dose of 1%.