Effectiveness of Pharmacist Interventions in Improving Medication Adherence and Clinical Outcomes in Patients with Diabetes Mellitus: A Meta-Analysis
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Abstract
Introduction: Efforts to control and prevent complications of diabetes mellitus require optimal therapeutic outcomes, which are strongly influenced by patient adherence to antidiabetic therapy. Non-adherence remains one of the main causes of inadequate glycemic control in individuals with type 2 diabetes.
Objective: This study aims to evaluate the effectiveness of pharmacist-led interventions in improving medication adherence and clinical outcomes among diabetic patients through a systematic review of randomized controlled trial (RCT) articles.
Methods: A systematic search was conducted using PubMed and PMC databases, and eligible studies were assessed for methodological quality using the Jadad Scale. Articles that obtained scores of 3 to 5 were included in a quantitative meta-analysis using RevMan, with interpretation focused on forest plots, confidence intervals, heterogeneity, and statistical significance. From 325 articles initially identified, six studies met all inclusion criteria and were eligible for analysis.
Results: The meta-analysis demonstrated that pharmacist interventions consistently improved medication adherence, as indicated by a heterogeneity p-value of 0.69, showing similarity across studies. Positive effects were also observed on key clinical outcomes such as reductions in HbA1C and fasting blood glucose levels. However, no significant effects were found on triglyceride levels or body mass index, as the analyzed studies displayed a consistent tendency that these parameters were not influenced by pharmacist interventions.
Conclusions: Overall, the findings indicate that pharmacist-led interventions play an important role in enhancing adherence and improving essential clinical outcomes in patients with type 2 diabetes mellitus.
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References
Astuti, C. M., & Setiarini, A. (2023). Faktor-faktor yang berhubungan dengan pengendalian kadar glukosa darah pasien diabetes melitus tipe 2 rawat jalan di Poliklinik Penyakit Dalam RSJ Prof. Dr. Soerojo Magelang Tahun 2013.
American Diabetes Association. (2024). Standards of Medical Care in Diabetes. ADA.
Ambachew, Y., Kahsay, S., Tesfay, R., Tesfahun, L., Amare, H., Mehari, A., & Gebrekidan, A. (2025). Prevalence of diabetes mellitus among patients visiting outpatient department of Ayder Referral Hospital, Ethiopia. International Journal of Pharma Sciences and Research, 6(2).
Bird, Y., Lemstra, M., Rogers, M., & Mararos, J. (2025). The relationship between socioeconomic status/income and diabetes prevalence. International Journal for Equity in Health, 14.
Butt, M., Ali, A. M., Bakry, M. M., & Mustafa, N. (2021). Impact of pharmacist-led diabetes intervention on HbA1C, medication adherence and quality of life. Saudi Pharmaceutical Journal, 24, 40–48.
Chai, A., & Ting-Su, A. (2026). Effectiveness of diabetes medication therapy adherence clinic in improving glycaemic control. Medical Journal of Malaysia, 75(3).
Garcia-Perez, L. E., Álvarez, M., Dilla, T., Gil-Guillén, V., & Orozco-Beltrán, D. (2023). Adherence to therapies in type 2 diabetes. Diabetes Therapy, 4, 175–194.
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2026). Sex and gender differences in risk and complications of type 2 diabetes. Endocrine Reviews, 37, 278–316.
Kirkman, M. S., Rowan-Martin, M. T., Levin, R., Fonseca, V. A., Schmittdiel, J. A., Herman, W. H., et al. (2025). Determinants of adherence to diabetes medications. Diabetes Care.
Lazuardi, A. (2024). Pengaruh edukasi melalui Home Pharmacy Care terhadap kepatuhan dan outcome klinik pasien diabetes mellitus tipe 2. Tesis. Universitas Gadjah Mada.
Morello, C. M., Chynoweth, M., Kim, H., Singh, R. F., & Hirsch, D. (2021). Strategies to improve medication adherence reported by diabetes patients. Annals of Pharmacotherapy, 45.
Perkeni. (2025). Konsensus Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia. PB Perkeni.
Rapoff, M. A. (2021). Adherence to Pediatric Medical Regimen. Springer.
Rafsanjani, Z. H., et al. (2020). Effect of a community pharmacist-delivered diabetes support program. The Diabetes Educator.
Rasdianah, N., Martodiharjo, S., Andayani, T. M., & Hakim, L. (2026). Gambaran kepatuhan pengobatan pasien DM tipe 2 di Puskesmas DIY. Indonesian Journal of Clinical Pharmacy, 5(4), 249–257.
Riskesdas. (2025). Hasil Utama Riset Kesehatan Dasar. Kementerian Kesehatan RI.
Rohman, F., et al. (2025). Pengaruh intervensi farmasis terhadap kepatuhan dan outcome klinis pasien diabetes mellitus.
Septiar, H. E., & Utami, P. (2025). Pengaruh konseling farmasis terhadap kualitas hidup dan kadar gula darah pasien DM tipe 2. Jurnal Farmasi Sains dan Praktis, 1, 29–34.
Srikartika, V. M., Cahya, A. D., & Hardiati, R. S. W. (2026). Analisis faktor yang memengaruhi kepatuhan obat pada pasien DM tipe 2. Jurnal Manajemen dan Pelayanan Farmasi, 6, 205–212.
Ting, C. Y., et al. (2026). Effectiveness of pharmacist-led structured group intervention in improving adherence and glycaemic control. Research in Social and Administrative Pharmacy.
Utami, M. R., et al. (2026). Pengaruh leaflet dan reminder terhadap outcome klinik dan kepatuhan pasien DM.
Wishah, R. A., Al-Khawaldeh, O. A., & Albsoul, A. M. (2020). Impact of pharmaceutical care interventions on glycemic control. Diabetes & Metabolic Syndrome.
Withidpanyawong, U., Lerkiatbundit, S., & Saengcharoen, W. (2024). Family-based pharmacist intervention for type 2 diabetes. Patient Education and Counseling.
World Health Organization. (2023). Global Report on Diabetes. WHO.